Effects of vitamin C supplementation on Chinese sausage-induced liver damage in rats

Contamination of nitrosamine compounds in Chinese sausages and the relevant hepatoxicity have been reported. This study was conducted to evaluate effects vitamin C (VC) supplementation on sausage contaminated with N-nitrosodimethylamine (NDMA)-induced liver damage metabolomic changes. Rats were orally administered NDMA at levels overpassing its safety limit. In some experiments, VC additionally via drinking water rats for 25 weeks. Serum samples collected from measurement profiles by using gas chromatography–mass spectrometry. Compared group alone, additional treatment, all serum biochemical parameters indicating hepatic significantly alleviated, which suggested an improved function supplementation. Metabonomic analysis showed notable changes metabolites VC-supplemented as compared that especially those involved regulation amino acid or energy lipid metabolism and/or anti-oxidative function. indicates supplement parallel long-term exposure may attenuate promote recovery